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A recent article by Jon Jacobsen on Mad In America details a two-year community-led research effort into Post-SSRI Sexual Dysfunction, or PSSD. This is a really debilitating condition that involves sexual, emotional, and cognitive impairments that can persist long after someone stops using antidepressants. The research, which was conducted with more than 100 PSSD patients, suggests that neuroimmune processes might actually play a key role here. Out of 56 tested patients , 70% showed small fiber neuropathy and an incredible 97% tested positive for autoantibodies that are linked to autonomic dysfunction. Jacobsen also shares his own nearly 20-year struggle with PSSD, pointing out symptoms like anhedonia and emotional blunting, and he calls for more research into immune-mediated mechanisms to validate and treat this condition, which is often-dismissed. This work, which is supported by the Iatrogenic Neuroimmune Disease Association, aims to spark more scientific inquiry and raise awareness.
Reference
Jacobsen, J. (2025, May 10). Two decades of PSSD: A life stolen by antidepressants. Mad In America. https://www.madinamerica.com/2025/05/two-decades-of-pssd-a-life-stolen-by-antidepressants/)
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